Obésité viscérale, taille des particules LDL et profil inflammatoire athérogène

by Arsenault, Benoît

Abstract (Summary)
Objective: The objective of the présent study was to investigate the respective contributions of the small LDL phenotype and viscéral adipose tissue accumulation to the variation in inflammatory markers. Methods and results: Anthropométrie measurements, body fat distribution and plasma inflammatory markers were assessed in a sample of 197 adult maie volunteers. LDL particle size was measured using 2-16% nondenaturing polyacrylamide gradient gel electrophoresis and inflammatory markers were assessed by nephelometry (hs-CRP) and by ELISA (TNF-a and IL-6). Subjects with an elevated VAT accumulation ( > 130cm 2 ) were classified into two groups according to the 50th percentile of LDL particle size (251.7Â) and were compared to subjects with a low VAT accumulation ( < 130cm 2 ) and large LDL particles ( > 251.7Â). After adjustment for triglycéride levels, men with VAT accumulation > 130cm 2 and small LDL particles were characterized by higher TNFa levels compared to either men with similar VAT but with larger LDL particles or to men of the référence group (p < 0.04). A 2X2 ANOVA revealed that LDL size significantly contributed to the variance of TNF-a concentrations (p < 0.0001) with no independent contribution of VAT on TNF-a variation. Conclusions: Results of the study suggest that the small LDL phenotype of viscéral obesity is associated with variation in the inflammatory cytokine TNF-a. 5 S
Bibliographical Information:

Advisor:Després, Jean-Pierre

School:Université Laval

School Location:Canada - Quebec / Québec

Source Type:Master's Thesis



Date of Publication:12/01/2006

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