I. The synthesis of potential antimalarials : A. Carbinolamines related to quinine; B. Sulfonamides. II. The resolution of 3-fluoro-dl-tyrosine, and the determination of the acute toxicity of the optically active isomers. III. The synthesis of p-arsono-dl-phenylalanine. IV. A study of the proteins in some invertebrate body fluids

by Rapport, Maurice M.

Abstract (Summary)
Part I: The synthesis of two series of compounds, benzenesulfonanilides and carbinolamines related to quinine, are described. These compounds were prepared as potential antimalarials. Part II: The enzymatic resolution of N-benzoyl 3-fluoro-dl-tyrosine and the preparation of 3-fluoro-D- and L-tyrosine are described. A study of the acute toxicity of the optical isomers is also reported. Part III: The synthesis of p-arsono-N-acetylphenylalanine is described. Part IV: The chemical fractionation of the protein constituents of Panulirus Interruptus (spiny lobster) blood was repeated, and an electrophoretic study of the fractions, confirming the presence of at least three separate proteins, is described. Preliminary fractionations of the body fluids of Cancer Anthonyi (crab), Stichopus Californicus (sea cucumber), and Halitotis Fulgens (green abalone) are also reported.
Bibliographical Information:

Advisor:Joseph Blake Koepfli; Carl Niemann; Dan Hampton Campbell

School:California Institute of Technology

School Location:USA - California

Source Type:Master's Thesis



Date of Publication:01/01/1945

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