The epidemiological, clinical and therapeutic features of sporotrichosis from Instituto de Pesquisas Clínicas Evandro Chagas (Fundação Oswaldo Cruz ? Rio de Janeiro) from 2002 through 2004.
Perfil epidemiológico, clínico e terapêutico da Esporotricose no Instituto de Pesquisa clínica Evandro Chagas - Fiocruz, Rio de Janeiro, no período de 2002 a 2004
Since 1998, an increasing number of cases of sporotrichosis has been observed in the city of Rio de Janeiro and surrounding municipalities reaching epidemic proportions. We present the largest series of cases ever described in Brazil and the largest epidemic by zoonotic transmission worldwide.The epidemiological, clinical and therapeutic features of 572 cases of culture-proven human sporotrichosis are described. All patients were seen at the sporotrichosis outpatient clinic from Instituto de Pesquisas Clínicas Evandro Chagas (Fundação Oswaldo Cruz ? Rio de Janeiro) from 2002 through 2004. The cases were related to exposure to cats that also developed the disease. The most frequent clinical presentation was lymphocutaneous disease followed by localized cutaneous and disseminated cutaneous disease. Adult female patients predominated. Itraconazole capsules, 100 mg/day for a mean of 12 weeks, cured 96,5% of the cases, without serious adverse events.
Advisor:Armando Oliveira Schubach
School:Faculdades Oswaldo Cruz
Source Type:Master's Thesis
Date of Publication:03/17/2006