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Atenuação do vírus vacinal do sarampo: Infecção sub-ótima do tecido linfático e alteração do tropismo

by Condack, Cristian Eduardo

Abstract (Summary)
The mechanisms of measles virus (MV) vaccine attenuation are insufficiently characterized. Because the vaccine strain can enter cells through CD46 in addition to the primary MV receptor signaling lymphocyte activation molecule (SLAM, CD150), we asked whether and how its tropism is altered. In human tonsillar tissue, this vaccine strain infectsnaive (CD45RA+ CD62L+) T lymphocytes, which express SLAM very infrequently, with much higher efficiency than do wild-type strains. By contrast, it infects B-lymphocytes, macrophages, and NK cells with significantly lower efficiencies than those of wild-type strains. Infection levels by wild-type strains correlate with the frequency of SLAMexpression, and are highest in B-cells, which are 40-55% infected. SLAM-expressing Tcells are more readily infected by all MV strains than are SLAM-expressing B-cells. Thus, vaccine attenuation may be caused by tropism alteration in combination with suboptimalreplication.
This document abstract is also available in Portuguese.
Bibliographical Information:

Advisor:Silvana Maria Eloi Santos; Heliane Brant Machado Freire; Marcus Vinicius Melo de Andrade; Gustavo Eustáquio Brito Alvim de Melo; Andréa Teixeira de Carvalho

School:Universidade Federal de Minas Gerais

School Location:Brazil

Source Type:Master's Thesis

Keywords:ntígeno CD4 DeCS

ISBN:

Date of Publication:03/30/2008

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