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Étude des concentrations d'antioxydants plasmatiques après supplémentation en vitamines E et C au cours de la grossesse

by Gagné, Amélie

Abstract (Summary)
Preeclampsia (PE) is a syndrome characterized by hypertension and maternal proteinuria during pregnancy. Some studies have suggested that supplementation with vitamins (E and C) could decrease the incidence of PE. Women (n=100) from the International Trial of Antioxidants for the Prevention of PE study were collected at week 12-16 of gestation (prior to vitamins supplementation), then at weeks 24 and 32 of gestation. A second group of 15 preeclamptic women was also selected for this study. Vitamins were determined using high-performance liquid chromatography. The higher ?-tocopherol and coenzyme Q10 concentrations during pregnancy in non-supplemented women, with or without PE, could represent a naturally response against oxidative stress in pregnant women. The lower ratio of ?-/?-tocopherol, observed for the first time in supplemented pregnant women, suggest an increase in plasma ?-tocopherol due to dietary supplementation and/or a decrease in ?-tocopherol resulting from a competition for the intestinal absorption of tocopherols.
This document abstract is also available in French.
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Bibliographical Information:

Advisor:Julien, Pierre; Fraser, William Donald

School:Université Laval

School Location:Canada - Quebec / Québec

Source Type:Master's Thesis

Keywords:médecine

ISBN:

Date of Publication:01/01/2009

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