Étude des concentrations d'antioxydants plasmatiques après supplémentation en vitamines E et C au cours de la grossesse

by Gagné, Amélie

Preeclampsia (PE) is a syndrome characterized by hypertension and maternal proteinuria during pregnancy. Some studies have suggested that supplementation with vitamins (E and C) could decrease the incidence of PE. Women (n=100) from the International Trial of Antioxidants for the Prevention of PE study were collected at week 12-16 of gestation (prior to vitamins supplementation), then at weeks 24 and 32 of gestation. A second group of 15 preeclamptic women was also selected for this study. Vitamins were determined using high-performance liquid chromatography. The higher ?-tocopherol and coenzyme Q10 concentrations during pregnancy in non-supplemented women, with or without PE, could represent a naturally response against oxidative stress in pregnant women. The lower ratio of ?-/?-tocopherol, observed for the first time in supplemented pregnant women, suggest an increase in plasma ?-tocopherol due to dietary supplementation and/or a decrease in ?-tocopherol resulting from a competition for the intestinal absorption of tocopherols.