Activación del eosinófilo en la pancreatitis aguda.
Acute Pancreatitis (AP) is a pancreas inflammatory process that can affect to other
distant organ. AP exhibits a wide variability in its severity, in most cases the course is
fairly benign (mild AP) while in others it may progress to a more severe form (severe
AP) with local complications or systemic -inflammatory response which can led to
multiple organ dysfunction syndrome. Local inflammatory response is an early event in
AP and has been revealed neutrophils, macrophages and mast cells infiltrated in
pancreas; however, there is no information about eosinophil participation in this
Eosinophil development from the bone marrow, trafficking into tissues and activation
are mediated by a regulated process involving cytokines and chemokines, chemical
mediators secreted from leukocytes, endotelial cell and tissue resident cells. IL-5
cytokine is the most selective for eosinophils differentiation and eotaxin has a
selectively chemoattractant activity that regulates eosinophil trafficking.
There are no studies about eosinophils role in inflammatory process of acute
pancreatitis. Our study try to evaluate eosinophil responsability through the eosinophils
number quantification and eotaxin and IL-5 determination, cytokines involved in
differentiation, activation and survival eosinophil.
Results show a progresive increase in eosinophils number from inclusion to month
from acute onset, whereas eosinophils number remain in normal range. Serum IL-5
concentration increases at day 1 to 4, and become in normal values at day 5 after the
inclusion, similar fact to other proinflammatory cytokines. This results are in line with
eosinophil hematopoiesis activation in early phase. However, eotaxin concnetration is
similar to control from day 1 to day 2, and increases from day 4 to month. This results
suggest eosinophil activation in tissue and an inmunoregulatory role in inflammatory
process of acute pancreatitis.
Advisor:Mir Gisbert, Amparo; Benages Martínez, Adolfo
School:Universitat de València
Source Type:Master's Thesis
Keywords:bioquímica i biologia molecular
Date of Publication:03/13/2008