Restauración de volumen y morfología de ventrículo izquierdo mediante exclusión de zonas aneurismáticas, discinéticas o acinéticas de origen isquémico durante el proceso de revascularización quirúrgica.

by Cánovas López, Sergio Juan

Abstract (Summary)
ABSTRACT Introduction. Heart failure is growing in incidence and prevalence, with the most frequent etiology as ischaemic cardiomyopathy. There are several ways to treat this disease - isolated coronary artery bypass graft (CABG), left ventricular restoring, correction of mitral insufficiency, heart transplantation, left ventricular assist device and cell transplantation. Hypothesis. Left ventricular restoring thru exclusion of akinetic, diskinetic and aneurysmal left ventricle areas during surgical revascularization improves ejection fraction (EF), decreases left ventricular volumes and improves short and long term morbidity and mortality. Methods: In a 5 year period, 47 patients were included. The mean age was 61.59±9.26 years, with 59.5% in NYHA class III or IV. Mean parameters on magnetic resonance imaging were: end systolic volume (ESV) 135±40 ml, end diastolic volume (EDV) 194±61ml, ESV index: 75±27ml/m2, EDV index: 108±33 ml/m2, EF: 30±7%. On average, 3.33 bypass grafts were fashioned and in 13%, mitral annuloplasty was performed for moderate or severe mitral insufficiency. Results: Operative mortality was 2%, and the mean follow up was 29.79±18 months. Survival at 1, 3 and 5 years were 95%, 95% and 90% respectively with 86% of patients in NYHA class I and 14% in class II. EF improved from 30.6±7 to 41.1±9%, EDVI decreased from 108.3±33.5 to 82.2±32.4 ml/m2 and ESVI decreased from 75.7±27.4 to 51.3±20.2 ml/m2, with parameters having P values between <0.05 to <0.001. Conclusions: Left ventricular restoration can be achieved with a low morbidity and mortality and results in volume reduction and improvements in EF and functional class. The observed survival was better that the expected for this group of high risk patients.
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Document Full Text
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Bibliographical Information:

Advisor:Ponce Marco, José Luis; Montero Argudo, José Anastasio

School:Universitat de València

School Location:Spain

Source Type:Master's Thesis



Date of Publication:07/05/2007

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