Detecção de vírus entéricos em crianças com gastroenterite aguda e idoso institucionalizados em Campo Grande, MS
Enteric viruses play a major role in the etiology of viral gastroenteritis as animportant cause of infantile diarrhea in the world. A wide range of etiologicalagents has implications in the epidemiology of acute diarrheas. The detection ofenteric viruses among the elderly has been enhanced due to the possibility ofoutbreaks, and also because of the Public Health concern about the quality of life ofthis population, as technological progress has contributed to an increase in lifeexpectancy. The role of enteric viruses in acute infantile gastroenteritis in Brazil hasbeen well defined through different studies. However, few data about the occurrenceof these viruses in the adult population are available. In order to contribute to thisissue, this study defined the etiology of viral gastroenteritis in hospitalized childrenand institutionalized elderly in Campo Grande/MS. Astrovirus and calicivirus havebeen detected by Polymerase Chain Reaction (PCR) and adenovirus and rotavirusby a combined enzyme immunoassay for rotavirus and adenovirus (EIARA). Thisstudy comprised the analyses of stool samples of children under 3 years of ageadmitted to Santa Casa and University Hospital in Campo Grande/MS, and elderlypeople institutionalized at Asilo São João Bosco. Among the children, astrovirus(3,1%), calicivirus (7,6%) and adenovirus (3,6%) have been observed. Among the115 elderly people samples, 13 (11,3%) were positive for the viruses at issue. GroupA rotavirus was undetected in the elderly population and astrovirus, calicivirus andadenovirus accounted for 0,8%, 1,7% and 8,7%, respectively. The results of thisstudy reinforce the importance of a constant surveillance of enteric infections in childpopulation and also show the circulation of these viral agents among the elderly population institutionalized in Campo Grande, MS. Such findings constitute animportant tool to evaluate the results of the vaccine against Rotavirus A, used since2006 in the National Immunization Program (Calendário Nacional de Imunização)in Brazil.
Advisor:Divina das Dôres de Paula Cardoso; Willia M Eisner I Brito; Fabíola Souza Fiaccadori; Ana Rita Coimbra Motta de Castro; Inês Aparecida Tozetti
School:Universidade de Brasília
Source Type:Master's Thesis
Date of Publication:09/25/2008