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Hiperlactacidèmia secundària a l'ús d'antiretrovirals en l'edat pediàtrica

by Noguera Julian, Antoni

Abstract (Summary)
SUMMARY: Nucleoside analogue reverse trancriptase inhibitors (NRTIs) play a pivotal role in HAART regimens, which have demonstrated efficacy in reducing both morbidity and mortality from AIDS and mother-to-child transmission of HIV infection. NRTIs inhibit also DNA polymerase gamma, which is an essential protein for mitochondrial DNA replication in human cells. Mitochondrial toxicity has been identified as the common pathway in a group of side effects associated with the use of NRTIs, including hyperlactatemia and lactic acidosis. A prospective observational study of optimally-obtained venous lactate (LA) concentrations in two cohorts of children exposed to antiretrovirals was performed. Cohort 1 included 91 HIV-infected pediatric patients (51 girls, mean age: 8y; LA obtained every 6m); cohort 2 included 141 uninfected infants born to HIV-infected mothers and exposed perinatally to antiretrovirals (LA obtained at 6w and 3, 6 and 12m of life). In cohort 1 the incidence rate for hyperLA (range: 2.4-4.9 mmol/l) was 8.8 episodes per 100 HIV-infected patients-year, never associating clinical symptoms. Prevalence rate: 22% of the cohort. Only a younger age at the beginning of HAART and a shorter duration of this treatment were identified as statistically significant risk factors for hyperlactatemia. Fifty-two per cent of infants in cohort 2 developed hyperlactatemia with spontaneous evolution towards normal levels with age in most cases (peak levels of 8.06, 10.1, 7.28 and 4.1 mmol/l at 6w and 3, 6 and 12m, respectively). Three girls presented a slight and self-limited delay in psychomotor development. Only the gestational use of didanosine was associated with a higher risk of hyperlactatemia. Considering that most cases of hyperlactatemia were symtom-free and the mild and self-limited evolution of the children who presented with neurologic symptoms, the random determination of LA would not be justified in any of these patients.
This document abstract is also available in Catalan.
Bibliographical Information:

Advisor:Fortuny Guasch, Clàudia; Jiménez González, Rafael

School:Universitat de Barcelona

School Location:Spain

Source Type:Master's Thesis

Keywords:obstetrícia i ginecologia pediatria radiologia medicina física

ISBN:

Date of Publication:07/08/2005

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