Soroprevalência da infecção pelo vírus da hepatite B e avaliação da imunidade vacinal em cirurgiões-dentistas de Goiânia-GO
HBV is considered the major occupational risk agent for dentists. The hepatitis B vaccination is hardly recommended to these professionals who have frequent contact with blood and saliva from patients. To determine the HBV infection rate as well as the vaccine immunity for dentists from Goiânia-GO, a randomized sample of 678 professionals participated in this study. The participants filled out a questionnaire about HBV infection risk factors and vaccination, and blood samples were collected to detect the serological markers HBsAg, anti-HBs and anti ?HBc. All dentists gave their written consent to the procedure and this study was approved by the Ethical Committee in Human and Animal Research from the Clinical Hospital of the Federal University of Goias (n. 110/2003). HBV infection marker was found in 41 (6.0%) dentists. None of them was HBsAg positive. HBV positivity were related to the male gender (OR=2.08; CI=1.09-3.97), the length of time working as a dentist (p<0.001) and the use of incomplete personal protective equipment (PPE) [p<0.05]. Among the anti-HBcAg positive samples (n=41), viral DNA was detected by PCR in PS1-PS2 segment in the second amplification in two samples (4.9%). Among the participants the vaccinated prevalence was high, 98.4% (667/678), although 77 dentists said they did not do the complete three doses series of the vaccine or they were not sure if they did it. Among 667 vaccinated dentists, 580 (87.0%) had anti-HBs positive result. The index goes to 88.3% if the vaccination schedule was completed. The quantitative anti-HBs assay was done to 313 blood samples (49.8%) from 629 vaccinated dentists anti-HBcAg negatives, and the concentration result <10 UI/L was found in all of serum that had negative and equivocal result in qualitative assay. However, 48 (20.3%) anti-HBs positive samples had as a result <10 UI/L in quantitative assay. The HBV prevalence in this group of dentists was lower than the endemic pattern of the general population, as well as the other health care workers in this region and of the dentists from other Brazilian regions that, associated with the high prevalence of vaccinated dentists and vaccine immunity, can represent a positive impact of the vaccination program with also the evident high adherence to the others standard precautions among the dentists.
Advisor:Divina das Dôres de Paula Cardoso; Sonia Maria Fernandes Batista; Marcelo Medeiros; Fabíola Souza Fiaccadori; Vânia Cristina Marcelo
School:Universidade de Brasília
Source Type:Master's Thesis
Keywords:HBV Hepatitis B dentist Brazil
Date of Publication:02/25/2008