Vascular Tissue Engineering Scaffolds from Elastomeric Biodegradable Poly(L-lactide-co-?-caprolactone)(PLCL) via Melt spinning and Electrospinning
The main objective of this study was to demonstrate the feasibility of fabricating vascular tissue engineering scaffolds via two different approaches, namely; melt spinning and electrospinning from elastomeric biodegradable poly(L-lactide-co-?-caprolactone) (PLCL) copolymers.
Overall, the tubular scaffolds had porosity exceeding 70% and the mechanical properties exceeded the transverse tensile values of the natural arteries of similar caliber. The morphology was also characterized as well as the fiber diameters and the pore sizes of the structures.
In addition to spinning the polymer separately into melt spun and electrospun constructs, the novel approach in this study has been to successfully demonstrate that these two techniques can be combined to produce a two layered tubular scaffold containing both melt spun fibers and electrospun nanofibers.
Advisor:Martin W. King; Hechmi Hamouda; Stephen Michielsen
School Location:USA - North Carolina
Source Type:Master's Thesis
Keywords:textile and apparel technology management
Date of Publication:04/26/2006