Using electron capture dissociation fourier transform ion cyclotron resonance mass spectrometry to study modified polypeptides [electronic resource] /

by Woodling, Kellie Ann.

ABSTRACT: The phosphorylation of serine, threonine and tyrosine residues plays a vital role in many aspects of protein expression and function. Protein phosphorylation is a reversible process that acts as a molecular switch, controlling pathways in metabolism, signal transduction and cell division. Because the phosphorylation of many proteins has been shown to alter the structure and function of the protein, localization of the site of modification has increasingly been studied in the last few years.