Synthesis of Structures Related to the Capsular Polysaccharide of Neisseria meningitidis Serogroup A and to Mycothiol
This thesis describes the synthesis of structures related to the capsular polysaccharide of Neisseria meningitidis serogroup A and the synthesis of analogues of mycothiol, a compound produced by Mycobacterium tuberculosis. The first part of the thesis describes the synthesis of structural elements present in the native capsular polysaccharide of Neisseria meningitidis serogroup A. In this part, an improved synthesis of 2-azido-2-deoxy-D-mannopyranose is included. The second part of the thesis describes the formation of stable C-phosphonate analogues related to the capsular polysaccharide. The last part outlines the formation of analogues of mycothiol, where the syntheses of a bicyclic analogue and a thioglycosidic analogue are described.
Source Type:Doctoral Dissertation
Keywords:NATURAL SCIENCES; Chemistry; Organic chemistry; Neisseria meningitidis; Capsular polysaccharide; Mycobacterium tuberculosis; Mycothiol; organisk kemi; Organic Chemistry
Date of Publication:01/01/2007