STUDY OF INFECTION AND DISEASE IN DOG (Canis family) BY Leishmania (Leishmania) chagasi in an endemic area on the island of St. Louis-Maranhão, Brazil
A cohort prospective study was carried with 350 dogs of various ages at localities Vila Novaand Bom Viver in the municipality of Raposa-MA, from March of 2002 to December of 2003.The objective is to avaluate the behavior of L. (L.) chagasi infection. The chosen areas are aresult of the disordered occupation process, contributing with 60% of LVH and LVC cases thatwere notified by the municipal district. At first, the procedure was made by doing thepopulational inquiry the two places by means of canine census. The study was processed intwo phases, with interval of 7 months among the same ones. In the first phase, 350 dogsparticipated of the study and by a visiting process a questionnaire with epidemiological,demographical, clinical and behavioral data about the dogs was applied. The testing ofMontenegro intradermoreaction (IDRM) was made with the antigen of L. (L.) amazonensisand adapted for dogs, serological examination testing Enzyme Linked Immunsorbent Assay(ELISA), clinical e parasitical were also made in positive animals to IDRM and/or ELISAtests. Starting from clinical and immunological parameters already referred in literature, weredefined four diagnoses categories, classifying the dogs according to its evolutionary course innot infected dogs (195), infected (100), Oligosymptomatic sick (41) and polysymptomatic sick(14). The second phase was accomplished with application of the same tests of the first phasewith 230 dogs, that reduction was due in function of the losses (36,28%) caused by death,address change and missing. The positive dogs for an or both tests were accompaniedbimonthly with reevaluation of the clinical exams. The initial and final prevalence andincidence of the infection were 8,57%, 6,52% and 8% for IDRM; by ELISA 39,71%, 32,6%and 16%; for ELISA and IDRM 44,29%, 37,39% and 21,6% respectively. In what the clinicalform refers, the dogs were classified in the following way: infected (28,57%),oligosymptomatic sick (11,71%) and polysymptomatic sick (4%). in agreement with thestatistical analyses not adjusted and adjusted, the variable age, race, secondary lesion, physicalcondition and place were associated the infection for L. (L.) chagasi. The infection for L. (L.)chagasi was present in 52,97% of the canine population of Vila Bom Viver and 34,55% inVila Nova, demonstrating that in endemic area happens the intense and active circulation ofLeishmania.
Advisor:RICHARD PEREIRA DUTRA
School:Universidade Federal do Maranhão
Source Type:Master's Thesis
Keywords:L. (L.) chagasi Infected Prevalence Incidence Infection
Date of Publication:01/28/2004