Study on the Natural Products from the Formosan Soft Coral Cladiella australis

by Wu, Ming-Hsuan

Abstract (Summary)
The organic extracts of Formosan soft coral Cladiella australis, collected along the coast of Kenting, Taiwan. Investigation on C. australis has led to the isolation of ten compounds 1-10, including six new compounds, australin A (1), australin B (2), australin C (3), australin D (4), (24S)-3£]-acetoxy-24-methylchloest-5-en-21-oic acid (6)¡Bcladiosulfone (10), and three compounds were first isolated from the natural sources, 5'-acetylthymidine (7), 2'-deoxy-3'-O-acetylthymidine (8), p-vinylbenzyl alcohol (9), and one know compounds (24S)-3£] -hydroxy-24-methylchloest-5-en-21-oic acid (5). Structures of these compounds were determined on the basis of spectroscopic evidences (including MS, IR, 1D and 2D NMR). Cytotoxicity of these compounds toward various cancer cell lines has also been determined.
Bibliographical Information:

Advisor:Chang-Yih Duh; Yang-Chang Wu; Jyh-Horng Sheu

School:National Sun Yat-Sen University

School Location:China - Taiwan

Source Type:Master's Thesis

Keywords:diterpene cladiella australis


Date of Publication:07/22/2003

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