The Study of N-Acylpyridinium SaltChemistry and Its Application in the Asymmetric Synthesis of Streptomyces SS20846A

by Homer, Holly K.

Abstract (Summary)

The first part of this research was directed towards a study of the mechanism of N-acylpyridinium salt chemistry. Comparison of de?s obtained from organometallic additions to the pyridinium salt versus analogous non-organometallic additions would show whether chelation of the metals plays a key role in the mechanism. The second focus of this research was on the use of chiral N-acylpyridinium salt chemistry in the asymmetric synthesis of Streptomyces SS20846A, a natural product isolated from a soil sample in Greece which has a restrictive action on the digestive system.

Bibliographical Information:

Advisor:Dr. Daniel L. Comins; Dr. Suzanne T. Purrington; Dr. Binghe Wang

School:North Carolina State University

School Location:USA - North Carolina

Source Type:Master's Thesis



Date of Publication:04/03/2000

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