The Study of N-Acylpyridinium SaltChemistry and Its Application in the Asymmetric Synthesis of Streptomyces SS20846A

by Homer, Holly K.

The first part of this research was directed towards a study of the mechanism of N-acylpyridinium salt chemistry. Comparison of de?s obtained from organometallic additions to the pyridinium salt versus analogous non-organometallic additions would show whether chelation of the metals plays a key role in the mechanism. The second focus of this research was on the use of chiral N-acylpyridinium salt chemistry in the asymmetric synthesis of Streptomyces SS20846A, a natural product isolated from a soil sample in Greece which has a restrictive action on the digestive system.