I. Studies on mixed anhydride systems. II. Studies of the alpha chymotrypsin catalyzed hydrolysis of specific substrates

by Mower, Howard F.

Abstract (Summary)
The synthesis and purification of p-nitrobenzoic-acetic mixed anhydride, p-methoxybenzoic-acetic mixed anhydride and benzoic-acetic mixed anhydride is described. The thermodynamic constants for the disproportionation reaction have been determined. A mechanism for this reaction is discussed. Measurements of the interaction of acetic and benzoic acids with the acetic-benzoic anhydride system have been made. The cleavage of the mixed anhydrides with nucleophilic agents is described. The synthesis of the following compounds is described: N-trimethylacetyl-L-tyrosinhydrazide, N-dichloroacetyl-L-tyrosinhydrazide, N-formyl-L-tyrosinhydrazide, N-trichloroacetyl-L-tyrosinamide and N-acetyl-L-cysteic acid carboxylamide. The kinetic constants for the [alpha] chymotrypsin hydrolysis of these substances are reported.
Bibliographical Information:

Advisor:Carl Niemann

School:California Institute of Technology

School Location:USA - California

Source Type:Master's Thesis



Date of Publication:01/01/1956

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