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Studies on Secondary Metablites of the Formosan Soft Coral Sinularia gibberosa

by Hsieh, Ya-ting

Abstract (Summary)
Investigation on the chemical constituents of the Formosan soft coral Sinularia gibberosa, collected by hand using scuba off the coast of Kenting, had led to the isolation of seven new cembranoids , gibberorenes A-G¡]2-8¡^, three new sterols, gibberoketosterol B¡]10¡^, gibberoepoxysterol¡]11¡^, gibberoketosterol C ¡]12¡^ along with two known compounds, (1Z,3E,7E,11S,12S,14S)-11,12-epoxycembra-1,3,7 -trien-14-ol¡]1¡^and gibberoketosterol¡]9¡^. The structures of 1-12 were elucidated on the basis of extensive spectroscopic analysis, including IR, MS, 1D, and 2D NMR. Cytotoxicities of 1-12 against a limited panel of cancer cell lines were also evaluated. Among these metablites, compounds 9 and 11 were found to exhibit moderate cytotoxicity toward MCF-7, A549, MDA-MB-231, and HepG2 tumor cells. The ability of 9 and 10 to inhibit the pro-inflammatory iNOS and COX-2 expression of LPS-stimulated RAW264.7 macrophage cells has been also estimated.
Bibliographical Information:

Advisor:Jhy-Horng Sheu; Ping-Jyun Sung; Chang-Yih Duh

School:National Sun Yat-Sen University

School Location:China - Taiwan

Source Type:Master's Thesis

Keywords:secondary metablites sinularia gibberosa soft coral

ISBN:

Date of Publication:07/31/2006

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