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Studies on the Natural Products of the Formosan Soft Corals Sinularia leptoclados and Sinularia nanolobata

by Shiue, Ru-Ting

Abstract (Summary)
The chemical constituents of organic extracts of two Formosan soft corals Sinularia leptoclados and Sinularia nanolobata were studied. Investigation on S. leptoclados has led to the isolation of eight norditerpenes (1-8), including four new compounds, scabrolide A (1), leptolide A (2), leptolide B (3), leptolide C (4) and four know compounds (5-8), (11, 12)-epileptolide (5), ineleganolide (6), (1R*,5R*,8R*,10S*,11S*)¡V11¡Vhydroxyl¡V1¡Visopropenyl¡V8¡Vmethyl¡V3,6¡Vdioxo¡V5,8¡Vepoxycyclotetradec¡V12¡Vene¡V10,12¡Vcarbolactone (7) and (1R*,5R*,8R*,10S*,11R*)¡V11¡Vhydroxyl¡V1¡Visopropenyl¡V8¡Vmethyl¡V3,6¡Vdioxo¡V5,8¡Vepoxycyclotetradec¡V12¡Vene¡V10,12¡Vcarbolactone (8). Also, investigation on the chemical constituents of S. nanolobata has led to the isolation of two new compounds (9-10), nanolobatallin A (9) and nanolobatallin B (10). The structures of the new metabolites were determined on the basis of spectroscopic analyses, including MS, IR, 1D and 2D NMR. The cytotoxicities of the isolates against the NUGC, HONE-1, KB and Hepa59T/VGH cancer cell lines were studies. Compounds 7, 8 and 10 showed moderate cytotoxicity against KB and Hepa59T/VGH cancer cell lines. Compound 9 exhibited moderate cytotoxicity against Hepa59T/VGH cancer cells.
Bibliographical Information:

Advisor:Jung-Nan Lin; Yung-Chang Wu; Jr-Hung Sheu

School:National Sun Yat-Sen University

School Location:China - Taiwan

Source Type:Master's Thesis

Keywords:sinularia nanolobata leptoclados formosan soft corals

ISBN:

Date of Publication:08/21/2002

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