Studies on the Natural Products of a Formosan Soft Coral
The chemical constituents of organic extracts of a Formosan soft coral Sinularia lochmodes (Kolonko) (collected at Ken-Ting in Taiwan) was studied and isolated twelve nature compounds (1¡V12), including seven new compounds, lochmodesolides A¡VE (1¡V5), 4,6-dibromo-(2',5'-
dibromophenoxy) anisole (6), 3£],11-dihydroxy-5£],6£]-expoxy-24-
methylene-9,11-secocholestan-9-one (7), and five know compounds (8¡V12),(1R*,5R*,8R*,10S*,11R*)-11-hydroxyl-1-isopropenyl-8-methyl-3,6-dioxo-5,8-epoxycyclotetradec-12-ene-10,12-carbolactone (8), (1R*,
8-epoxycyclotetradec-12-ene-10,12-carbolactone (9), norcembrenolide 5 (10), scabrolides A (11), ineleganolide (12). The structures of 1¡V12 were elucidated by spectroscopic evidences (1D NMR, 2DNMR, IR and MS) and chemical method. The stereochemistry of compound 5 was further confirmed by single-crystal X-ray diffraction analyses.
Compounds 8 and 9 showed moderate cytotoxicity against KB, Hela, Med, NCI, DLD-1 and Hepa59T/VGH cancer cell lines.
Advisor:Yang-Chang Wu; Jyh-horng Sheu; none; Chang-Yih Duh
School:National Sun Yat-Sen University
School Location:China - Taiwan
Source Type:Master's Thesis
Date of Publication:08/09/2004