Studies on the Natural Products of the Formosan Soft Coral Sinularia sp.

by Hsieh, Chi-hua

The chemical constituents of EtOH extracts of the soft coral Sinularia sp. have led to the isolation of nature compounds¡]1-12¡^,sinularioperoxides A-D¡]1-4¡^, sinulariolins A-D¡]5-8¡^, 1a,3b-Dihydroxy-24-methylencholesta-5,9-diene¡]9¡^,¡]3S¡^-3,7-Dimethyl-nona- 6,8-dienoicacid¡]10¡^, ¡]2¢S¡^-Ethyl¡]5¢E¡^-5-(2¢,6¢-dimethylocta-5¢,7¢-dienyl)furan-3-carboxylate¡]11¡^, and one know metabolite, 3'R,4'-((2R, 4S)-2-hydroxy-4-acetoxy-2,6,6-trimethyl-cyclohexylidene)but-3'-en-2'-one¡]12¡^, respectively. Compounds 1-11 are new and 12 is a know metabolite, which had been isolated from the brown alga and the plant. The structures of 1-12 were elucidated by the interpretation of spectroscopic data¡]UV, MS, IR, 1D and 2D NMR¡^.