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Studies on Bioactive Diterpenoid Constituents from Formosan Taxus sumatrana

by Cheng, kuen-ching

Abstract (Summary)
­^¤åºK­n The search for potential anti-tumor agents among taxane diterpenes is becoming an interesting and essential issue in the last two deades. Interest in Taxol was also around strongly when Taxol was discovered as effective clinical anti-cancer drug. In order to discover new Taxol derivatives, the twigs and leaves of the Formosan Taxus sumatrana (Miq) de Laub. growing in the forest of Kaohsiung Liukuei area was collected for phytochemical and anti-tumor investigation. The structures of these taxane diterpenes and their derivatives were established primarily on the basis of their spectral analysis and chemical derivatization. The application of NMR techniques included 1H NMR, 13C NMR, DEPT, COSY, HMQC, HMBC, NOESY and another physical methods which include MS, UV, IR and optical rotation. In this experiment, we have identified as taxinine M (67)¡B 2£\,5£\-dihydroxy-7£],9£\,10£],13-tetraacetoxy-4(20),11-taxadiene (68) ¡B 2£\-deacetyl-5£\-decinnamoyl-taxagifine (69) ¡Bwalifoliol (70) ¡B10-deacetyl-baccatin III (71) ¡B10,13-deacetyl-abeo-baccatin IV (72) ¡B 10-deacetyl-13-oxo-baccatin III (73) ¡B 19-hydroxy-13-oxo-baccatin III (74) ¡A 19-hydroxy-10-deacetyl-baccatin III (75) ¡B19-hydroxy- baccatin III (76) ¡B taxayuntin G (77) ¡B 10-deacetyl-10- oxo-baccatin III (78) ¡B tasumatrol E (79) ¡B tasumatrol F (80) and tasumatrol G (81), among them, compounds 79¡B80¡Band 81 were new compounds from natural source. All of these compounds were sent to medical science research institute in Taiwan for anti-tumor in vitro test. The investigation of their structures and activity relationship is now in progress.
Bibliographical Information:

Advisor:none; none; none

School:National Sun Yat-Sen University

School Location:China - Taiwan

Source Type:Master's Thesis

Keywords:taxus

ISBN:

Date of Publication:02/03/2004

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