Details

Structure and Dynamics of the Copper-binding Octapeptide Region in the Human Prion Protein

by Riihimäki, Eva-Stina

Abstract (Summary)
The copper-binding ability of the prion protein may be closely connected to its function. Identifying the exact function of the prion protein can clarify the underlying mechanism in prion diseases. In this work, the copper-binding octapeptide region in the human prion protein has been studied. The structural characteristics of the binding site are examined by quantum chemical structural optimization. The calculations aim at identifying a substitute for copper(II) to be used in NMR-spectroscopic studies of the copper-binding region. The dynamical and structural features of the peptide region are investigated in molecular dynamics simulations. Aspects of importance in the development of model systems in molecular dynamics simulation are addressed.
Bibliographical Information:

Advisor:

School:Kungliga Tekniska högskolan

School Location:Sweden

Source Type:Master's Thesis

Keywords:NATURAL SCIENCES; Chemistry; Inorganic chemistry; Inorganic chemistry; prion protein; copper; molecular dynamics simulation; solvation model; metal ions; coordination; Oorganisk kemi

ISBN:

Date of Publication:01/01/2005

© 2009 OpenThesis.org. All Rights Reserved.