Structural studies of homologous recombination in bacteria

by 1978- Xing, Xu

RecA is a central player in homologous recombination, an essential DNA repair pathway. It catalyzes the key steps of homology search, strand exchange and branch migration in the process. It also regulates the SOS response. The structures of uncomplexed E. coli RecA and its complex with ADP were solved 15 years ago. In both structures, RecA is packed in a right-handed helical filament with a pitch of 82.7Å. In