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Stress Reducing Effects of Oxytocin in a Maternal Separation Paradigm

by O’Connell, Keely Jane

Abstract (Summary)
This study compared the effects of centrally and peripherally administered oxytocin (OT) on HPA axis activity and the presence of both stress-induced active and passive behaviors in female guinea pig pups (Cavia porcellus) after 180-min of isolation . In Experiment 1, one dose of oxytocin (10?g/.2ml) was injected subcutaneously into the periphery. Plasma cortisol levels were reduced after 180-min of isolation and two passive behaviors, eye-closure and crouch, were reduced as well with the administration of oxytocin. In Experiment 2, two different doses (10?g/.2ml and 20?g/.2ml) were injected into the periphery with no significant results. In Experiment 3 one dose of oxytocin (1?g/5?l) was infused centrally. Plasma cortisol levels were marginally reduced after 30-min of isolation. Both the active and passive behaviors were unchanged.
Bibliographical Information:

Advisor:

School:Wright State University

School Location:USA - Ohio

Source Type:Master's Thesis

Keywords:oxytocin stress maternal separation guinea pigs

ISBN:

Date of Publication:01/01/2008

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