Strategies for the evaluation of the exposition to the lead: comparative studies of the biological pointers and related effect.
Biological indicators are important tools for the evaluation of health impairment induced by chemicals exposure, mainly when they are associated with biochemical and physiologic changes. The principal goals of this study are to evaluate the possibility of the use of the Na+K+ATPase enzyme as leadexposure indicator through animal experimentation. , and to investigate deeply the relation of recovery % of ALA-D, Pb-U, ALA-U, and ZPP in lead occupational exposed population. The results showed the inhibition of the activity of the Na+K+ATPase by the metal action since the intern dose of29,18amp;#956;g/dL of lead in blood and the very good correlation between the effect indicators. The early renal effect (inclusions bodies) found in this study, have confirmed that kidney is straight involved with the poisoning process, showingthe important role of the recovery % of ALA-R. The recovery % of ALA-D proved to be more sensible and specific effect indicator than the other forms of the enzyme, in both evaluations. Because of these findings, it can be usedin the admission occupational exam with together lead in blood. In the evaluation of workers exposed, the results pointed out the important use of Eletromiography as routine exam in the surveillance medical. These results also indicated a inclusion of Pb-U, ALA-U E ZPP in the monitoring biologicprograms because they assed with precision the exposition, the are noninvasive and the biologic matrix is easy to collect. In this study, two evaluation steps were possible to be done, allowing to complete the findings and the comprehension for the developing lead exposure interpretation.
Advisor:Josino Costa Moreira
School:Faculdades Oswaldo Cruz
Source Type:Master's Thesis
Date of Publication:12/11/2001