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STATISTICAL APPROACH TO DETECT AND ESTIMATE HORMESIS

by DENG, CHUNQIN

Abstract (Summary)
Hormesis is described as a dose response relationship that is stimulatory at low doses, but inhibitory at higher doses in dose-response experiments. In order to be able to incorporate hormesis in quantitative risk assessment and regulatory decision-making activities, hormesis must be quantitatively defined and statistically tested. A non-parametric rank test and a model-based approach are proposed to detect hormesis. In non-parametric rank test, the Mark-Wolfe’s procedure is applied to test the null hypothesis H 0 : ? 1 =...=? k vs. the alternative hormesis hypothesis (or umbrella hypothesis) H A2 : there exists an l, 1Bibliographical Information:

Advisor:

School:University of Cincinnati

School Location:USA - Ohio

Source Type:Master's Thesis

Keywords:hormesis dose response non parametric model based whole effluent toxicity

ISBN:

Date of Publication:01/01/2001

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