Soropositividade para o vírus da hepatite B e determinação do índice de resposta vacinal em cirurgiões-dentista de Campo Grande (MS)
Seropositivity for hepatitis B virus, vaccination coverage and vaccine response in dentists from Campo Grande, Mato Grosso do Sul, Brazil
Hepatitis B virus infection represents an occupational hazard for health care workers. This study investigated the seropositivity for hepatitis B virus (HBV), the vaccination index, and the vaccine response index in dentists from Campo Grande (MS). Blood samples from 474 dentists were analyzed by enzyme-linked immunosorbent assay to detect the serological markers: HBsAg, anti-HBs, and anti-HBc. The HBsAg positive samples were tested for anti-HBc IgM, HBeAg, and anti-HBe. A total of 51 (10.8%) dentists showed seropositivity for HBV. Three (0.6%) were HBsAg/anti-HBc/anti-HBe positive, 43 (9.1%) were anti-HBc/anti-HBs positive, and five (1.1%) were only anti-HBc positive. Viral DNA was detected by polymerase chain reaction in nine (17.6%) out of 51 HBV seropositive samples. A vaccination index of 96.6% was observed, although 73.1% completed the three-dose schedule. Excluding 46 HBV seropositive individuals from 458 who reported vaccination, 412 were analyzed for vaccine response index. It was observed that 74.5% were anti-HBs positive; this percentage increased to 79.1% when three doses were administrated. The results showed a high vaccination index and a good rate of vaccine response; however, the occurrence of HBV infection and the failure in completing the three-dose schedule demonstrate the need for continual education programs and for more effective prevention strategies.
Advisor:Ana Maria Coimbra Gaspar; Regina Maria Bringel Martins; Divina das Dôres de Paula Cardoso; Marcelo Medeiros
School:Universidade de Brasília
Source Type:Master's Thesis
Keywords:soroprevalência hepatitis B dentists - vaccines seroprevalence
Date of Publication:06/12/2006