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Soroepidemiologic study about hepatitis B vírus infection (HBV) and evaluation of Butang vaccine seroconversion in teenagers living in the suburbs of Goiânia, Goiás

by da Silva, Michele Dias

Abstract (Summary)
To evaluate the seroepidemiology profile of the hepatitis B virus infection, and the response to Butang® vaccine in adolescents from a low-income region in the Metropolitan Area of Goiânia city Goiás 664 individuals with 12 to 19 years old were interviewed regarding socio-demographic and HBV risk factors After blood samples were collected and serum samples were tested for HBV markers (HBsAg, anti-HBs and anti-HBc) by enzyme-linked immunosorbent assay (ELISA) HBsAg positive samples were subtyped by ELISA and HBV DNA detected by polymerase chain reaction Positive samples were genotyped by restriction fragment length polymorphism (RFLP) method Three doses of 20amp;#956;g of the Butang® vaccine were offered to all susceptible adolescents and the vaccine response was evaluated nearly 45 days after A global prevalence of 5.9% (CI 95%: 4.3 ? 8.0) was found ranging from to 2.4% (CI 95%: 0.7 - 6.3) to 17.3% (CI 95%:11.0 - 26.0) All HBsAg positive adolescents were infected with HBV isolates of subtype adw2 and genotype A Age of 16 to 19 years attending in evening classes school B birth in other state and body piercing were independently associated to HBV positivity A total of 304 adolescents were susceptible to hepatitis B virus Of them 182 compliance with the full vaccine scheme and in 170 the vaccine response was evaluated All developed protector anti-HBs titers being the majority with titers higher than 1.000 mUI/mL The anti-HBs geometric means titers (GMT) were equal to 4.344 mUI/mL (CI 95%: 3.492 ? 5.404) These findings ratify the importance of hepatitis B vaccine to adolescents mainly to low income ones whose social conditions should support the viral dissemination The administration of the present scheme of Butang® shouldguarantee protective anti-HBs levels to individuals at a critical time for hepatitis B acquiring such as latter adolescence and adulthood
This document abstract is also available in Portuguese.
Bibliographical Information:

Advisor:Sheila Araújo Teles

School:Universidade Federal de Goiás

School Location:Brazil

Source Type:Master's Thesis

Keywords:teenagers Hepatitis B students vaccine evaluation

ISBN:

Date of Publication:12/09/2005

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