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SONOFLUIDIC MICRO-SYSTEMS FOR PRECISION-CONTROLLED IN-VIVO DRUG DELIVERY

by THACKER, JAMES H

Abstract (Summary)
In orthopaedics, current methods of drug delivery are technologically primitive in that they limit the control over dosing parameters including amplitude, frequency, and chronology of delivery. The research in this thesis works toward a sonofluidic delivery system that would allow control over these parameters. A drug-containing textile would be placed in-vivo at the delivery site, remaining non-permeated until the application of ultrasound. With ultrasound, the ambient fluid would permeate the textile, mix with the enclosed product, and release the product via diffusion. Chronologically separate delivery may be achieved by adjusting parameters of the textile and applied ultrasonic signal. This would allow delivery of product in controlled quantities, thus maximizing product absorption. This thesis discusses the design, fabrication, and testing of six generations of sonofluidic devices, along with future research directions, where recommendations are made for the design of a device conforming more to the standards of a commercial prototype.
Bibliographical Information:

Advisor:

School:University of Cincinnati

School Location:USA - Ohio

Source Type:Master's Thesis

Keywords:sonofluidics biomems microfluidics ultrasound sonocapillary laplace orthopaedic drug delivery orthopedic drub bmp2 bmp7 growth factors

ISBN:

Date of Publication:01/01/2007

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