Self assembled tweezer-type metalloreceptors for the recognition of nucleotides

by 1977- Plante, Jeffrey P.

Abstract (Summary)
Two different classes of molecular tweezers are synthesized and evaluated. The first consists of a self assembled tweezer, held together by metal chelation. The second class consists of a N3 ligand system that was able to chelate a metal and present a free lewis acidic site to incoming guests. The binding properties of multiple generations of this system were shown for the nucleosides and nucleotides. The system was characterized by x-ray crystallography, and the binding constants were determined by a fluorescent dye displacement assay. Also a receptor for diamines was examined based off of a design pioneered in the Glass Group, that consists of a quinolone-aldehyde that generates a novel fluorescent response. iii
Bibliographical Information:


School:Pennsylvania State University

School Location:USA - Pennsylvania

Source Type:Master's Thesis



Date of Publication:

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