Resultados inmediatos y tardíos de la angioplastia coronaria con stents liberadores de fármacos antiprolifertivos en pacientes con síndrome coronario agudo.

by Planas del Viejo, Ana María

Abstract (Summary)
ABSTRACT BACKGROUND.- Percutaneous coronary intervention has shown to be effective in patients with acute coronary syndromes (ACS). However, due to in-stent restenosis, the rate of clinical events in patients with ACS still remains high. Drug eluting stents (DES) have shown to reduce in-stent restenosis and target lesion revascularization, but its results in ACS population are controversial. OBJECTIVES.- To confirm whether DES are safer and more effective than bare metal stents (BMS) in patients with ACS. We considered clinical and angiographical objectives. The clinical primary end-point was the incidence of target lesion revascularization (TLR) at 1 year. Clinical secondary end-points were major adverse cardiac events (MACE) and the incidence of stent thrombosis at 1 year. An angiographic follow-up was performed from 1 year. The angiographic primary end-point was the incidence of in-stent restenosis. METHODS.- We conducted an observational study of 145 patients with ACS who were treated with DES. This group was compared with 138 patients treated with bare metal stents (BMS) in the preceding period. RESULTS.- The procedure was successful in all patients. At 1 year, the incidence of TLR was lower in the DES group than in the BMS group (7,6% vs. 19,6%, respectively; p=0,003), as were the rates of MACE (11,7% vs. 27,5%; p=0,001). There was no significant difference between the two groups in the rate of death (2,1% vs. 6,5%; p=0,06), myocardial infarction (3,4% vs. 2,1%;p=0,36) or stent thrombosis (2,1% vs 2,2%, respectively;p=0,82). In the angiographic follow-up the rate of in-stent restenosis was also lower in the DES group (13,7% vs. 33%; p=0,001) due to a lesser late luminal loss (1,94+0,91 vs 2,40+1,90;p=0,02). CONCLUSIONS.- In patients with ACS, implantation of DES is as safe as BMS. DES reduce the incidence of TLR and MACE at 1 year, and shows better angiographic results on the follow-up, reducing in-stent restenosis by 58% and late luminal loss by 64%. Angiographic pattern of in-stent restenosis was, more often, focal in DES and diffuse in BMS. No significant differences were seen in death, myocardial infarction or stent thrombosis. Stent thrombosis was related with ST elevation myocardial infarction procedures and larger stent length.
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Bibliographical Information:

Advisor:Chorro Gascó, Fco. Javier; Pomar Domingo, Francisco

School:Universitat de València

School Location:Spain

Source Type:Master's Thesis



Date of Publication:01/11/2008

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