Reparo ósseo utilizando enxerto de matriz orgânica bovina: análise histológica em calvária de coelhos

by Silveira, Rubens Jorge

Xenogenic graft of bone origin has been used to favor bone regeneration and toreduce autogenous bone needs. The purpose of this study was to evaluate thebone repair induced by particulate bovine organic bone grafted in rabbitcalvaria. Two standardized bone defects were prepared in both parietal of 20adult rabbits. The defects were filled by clot, autograft, medular organic bovinebone or cortical organic bovine bone. Thirty days following surgery animalswere killed; the calvaria were removed, fixed in formol, demineralized in EDTAand embedded in paraffin. Histological sections were stained in HE or MalloryTrichrome and analyzed by light microscope. On group filled with clot only thehalf of the defect was repaired by new bone tissue, which was formed fromlesion border, central area presented cellular connective tissue. In defects filledwith autograft almost all defect was repaired by bone tissue. Defects graftedwith medular or cortical bovine bone exhibited near ¼ of defect filled by bonetissue, formed from border, with central area occupied by fibrous connectivetissue. Almost all xenogenic grafts were reabsorbed, remaining few fragmentsthat were associated to foreign body giant cell reaction and few showing boneneoformation around. Therefore, the graft of organic bovine bone, medular orcortical, used in an isolated way, didn't favor the process of bone repair.