Red wine ingestion action upon sympathetic nervous system and endothelial function in hypertensive and hypercholesterolemic subjects

by Magalhães Andrade, Ana Cristina

Abstract (Summary)
Introduction: Moderate red wine intake is inversely associated with development of cardiovascular disease. Red wine effects in sympathetic activity and vascular reactivity are not fully understood. Methods: Muscle sympathetic nerve activity and flow mediated dilatation of brachial artery by ultrasound were evaluated in 10 hypercholesterolemic, 9 hypertensive, and 7 controls subjects before and after red wine intake during 15 days. Hemodynamic measures were done with Finometer: arterial blood pressure, heart rate, cardiac output, and systemic vascular resistance were assessed during mycroneurography. The sympathetic activity was evaluated during baseline, cold test and isometric exercise. Results: After 15 days of red wine intake, sympathetic activity increased significantly in hypertensives and hypercholesterolemics (p < 0.05). On the other hand, flow mediated dilation increased after red wine only in hypercholesterolemics (p < 0.05). Systolic and diastolic blood pressure as well as heart rate did not change significantly. Cardiac output increased in controls and systemic vascular resistance decreased during cold test in controls. Conclusion: There were similar increases in sympathetic activity in hypertensive and hypercholesterolemic subjects; however, endothelial function was restored only in the latter group, which suggests different mechanisms regulating endothelial function.
This document abstract is also available in Portuguese.
Bibliographical Information:

Advisor:Protasio Lemos da Luz; Patricia Chakur Brum; Francisco Antônio Helfenstein Fonseca; Whady Armindo Hueb; Edson Stefanini; Protasio Lemos da Luz

School:Universidade de São Paulo

School Location:Brazil

Source Type:Master's Thesis

Keywords: Endothelium/ultrasonography Hypercholesterolemia Hypertension Sympathetic nervous system Wine


Date of Publication:11/22/2006

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