Protective effects of Zinc-L-Carnosine/ Vitamin E on aspirin-induced gastroduodenal injury in dogs
Zinc-L-carnosine has protective effects against epithelial injury in cell culture and rodent models of gastrointestinal (GI) mucosal injury. This randomized double-blinded placebo-controlled study investigated the protective effects of zinc-L-carnosine in combination with alpha-tocopheryl acetate (vitamin E) on the development of aspirin-induced GI lesions in dogs. Eighteen healthy mixed-breed dogs were given 1 tablet (n=6) or 2 tablets (n=6) of 30 mg zinc-L-carnosine/ 30 IU vitamin E q12h PO, or a placebo (n=6) on Days 0 – 35. On Days 7 – 35, all dogs were given 25 mg/kg buffered aspirin q8h PO. Endoscopy was performed on Days -1, 14, 21, and 35, and GI lesions were scored using a 12-point grading scale. All dogs developed mucosal lesions. Treatment had no significant effect on gastric (p=0.31) or duodenal lesion scores (p=0.067). Zinc-L-carnosine/ vitamin E did not prevent gastric mucosal lesions in an aspirin-induced model for GI injury.
School:The Ohio State University
School Location:USA - Ohio
Source Type:Master's Thesis
Keywords:polaprezinc zinc l carnosine vitamin e dog gastroduodenal injury endoscopy aspirin
Date of Publication:07/15/2009