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Phenotypic changes in dendritic cells when challenged with cowpox virus [electronic resource] /

by DeBernardis, Justin R.

Abstract (Summary)
ABSTRACT: With the increasing threat of bioterrorism, the need to understand the pathological mechanisms behind poxvirus infections has become of paramount importance. Poxviruses are one of the most feared applications of bioterrorism, partly due to the virus rapid dissemination in the target population, as well as its high morbidity and mortality. Poxvirus, unlike many other viruses, maintains the ability to modulate its host s immune system in a manner that promotes its survival and infectivity. The objective of this study was to determine how poxvirus interacts with the host s primary antigen recognition system, dendritic cells (DCs), a major component of the immune system that has the ability to link the innate and acquired immune responses.
Bibliographical Information:

Advisor:

School:University of Florida

School Location:USA - Florida

Source Type:Master's Thesis

Keywords:research cowpox virus dendritic cells antigens cd14 tumor necrosis factor alpha interleukin 12 immunity cellular

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