The Pederin Family: A Synthetic Overview

by Kellar, Terry Allen

Abstract (Summary)
A comprehensive synthetic review of the pederin family of cytotoxins, including pederin, the mycalamides, and psymberin, is presented. A number of approaches to the synthesis of these molecules is covered, including pederic acid, the tetrahydropyranyl ring of pederin, the trioxadecalin ring of the mycalamides, and psymberin fragments. Coupling strategies for these compounds are also summarized. An overview of biological activity at various positions of mycalamide A, as well as some analogs, is given.
Bibliographical Information:

Advisor:Paul Floreancig; Kay Brummond; Kazunori Koide

School:University of Pittsburgh

School Location:USA - Pennsylvania

Source Type:Master's Thesis



Date of Publication:06/29/2006

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