ORGANIZATION AND EVOLUTION OF THE CYP2A-T GENE SUBFAMILY CLUSTER IN RODENTS, AND A COMPARISON TO THE SYNTENIC HUMAN CLUSTER
Genes from the cytochrome P450 (CYP) superfamily encode a diverse group of mono-oxygenases that play important roles in metabolism of both endogenous and exogenous compounds. A CYP2 gene cluster on mouse chromosome 7 was mapped and analyzed in detail, and compared to the homologous cluster on human chromosome 19. The mouse cluster includes twenty-two loci from the same six CYP2 subfamilies found in the human cluster. Parts of the two gene clusters are similar, but the data indicate that a significantly different series of duplication events created the modern gene organizations in the two species. The comparison of the mouse and human clusters provides new insights into the evolution of gene families, while the detailed analysis provides important information on specific mouse CYP2 genes. The syntenic CYP2 cluster on rat chromosome 1 is also being studied. Fourteen loci, from the same six subfamilies, have been found in this cluster.
School Location:USA - Ohio
Source Type:Master's Thesis
Keywords:cytochrome p450 gene family duplication cyp2a cyp2b cyp2f cyp2g cyp2s cyp2t
Date of Publication:01/01/2003