Novas imidazolidinas potencialmente esquistossomicidas: bioatividade de 2-Tioxo-Imidazolidin-4-onas frente a vermes adultos de Schistosoma mansoni (CEPA BH)

by Apolinário da, Andréa Cristina

Abstract (Summary)
New bioisosteres derivates of serie 5-benzilidene-3-(4-nitro-benzyl)-2-thioxoimidazolidin-4-one 10a-d and 5-benzylidene-3-[2-oxo-(4-nitro-phenyl)-ethyl]-2-thioxo-imidazolidin-4-one 12a-d were obtained. The synthesis was done begining with 2-thioxo-imidazolidin-4-one and ethyl 2-cyane-phenyl acrilates by Michael-like addition reaction at 5-position of imidazolinic ring. Then, was done substituition reaction at 3-position of imidazolidinic ring, using substituited benzyl or phenacylchloride or bromide. The chemical strutures of the news compounds was proved by infrarred and hydrogen nuclear magnetude ressonace spectroscopy. The synthetized compounds was tested for antischistosomal activity using Schistosoma mansoni (cepa BH) adults worms and they did not exhibit activity
This document abstract is also available in Portuguese.
Bibliographical Information:

Advisor:Suely Lins Galdino

School:Universidade Federal de Pernambuco

School Location:Brazil

Source Type:Master's Thesis

Keywords:2 tioxo imidazolidin 4 onas bioatividade novas imidazolidinas potencialmente esquistossomicidas quimica dos produtos naturais schistosoma mansoni vermes adultos


Date of Publication:02/16/2004

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