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Morphological and biochemical analysis of the synovia of rabbits immunized with type V collagen

by Ichicawa Ogido, Luciana Tsuzuki

Abstract (Summary)
We described an original model of experimental synovitis in rabbits immunized with collagen V with scant cellular infiltration, intense matrix remodeling and vasculitis. Morphological and biochemical analysis were realized in New Zealand female rabbits (N=20) immunization with type V collagen, compared with control rabbits. It was observed increase of collagen I, III and V, vascular lumen occlusion and scant inflammatory process. Biochemical analysis confirmed the fibrosis with increased synthesis of collagen. We postulate that synovial changes described in this model are consequence of collagen V particularities, which promotes immunologic and clinical manifestations similar to scleroderma
This document abstract is also available in Portuguese.
Bibliographical Information:

Advisor:Natalino Hajime Yoshinari; Eduardo Ferreira Borba Neto; Ibsen Bellini Coimbra; Emilia Inoue Sato; Claudia Goldenstein Schainberg; Natalino Hajime Yoshinari

School:Universidade de São Paulo

School Location:Brazil

Source Type:Master's Thesis

Keywords: DISEASE MODELS ANIMAL FIBRILLAR COLLAGENS/analysis RABBITS SYNOVITIS/chemically induced

ISBN:

Date of Publication:06/24/2005

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