Modelo experimental de quimioembolização hepática
Experimental model of chemoembolization hepatic
PURPOSE: An animal model to study the behaviour of liver tumor in rat and its response after use of transarterial chemoembolization. METHODS: We use 88 Wistar rats, all of them were females, adult, weight 175-284 g. Abdominal incison of three cm and implanted the Walker carcinossarcoma 256 at left lobule of the liver. The animals were divided into three grups, that received 100x103 , 200x103, and 300x103 cells. Followed up the animas to avaliate life standing and tumoral development. In another experiment was used 39 animals which already had Walker 256 tumor and we study the survival of the animals after treatment with 5-FU IP or 5-FU IA. RESULTS: The orevall tumor development rate were 100%. Tumor growth was fast, and devolopment metastases on old fase. The animals dead between 7º and 15º day. Its possible to do chemoembolization experimentaly, after the use of 5-FU the rate survival increased. CONCLUSION: The model with Walker 256 tumor developed here is easy to repoduce, efficient, with high tumor development rate observed, the life standing is about 9,96 ± 0,3 days. The chemoembolization experiment allows to assess several drugs.
Advisor:Manoel Odorico de Moraes Filho; José Huygens Parente Garcia; Paulo Ferdinando de Melo Oliveira
School:Universidade Federal do Ceará
Source Type:Master's Thesis
Keywords:Carcinossarcoma de Walker Quimioembolização Liver tumor model Chemoembolization Carcinoma Neuroendócrino 256
Date of Publication:09/09/2004