Mitral Cell Dendritic Development in the Mouse Main Olfactory Bulb
MCs progressed through a broad spectrum of transitional morphologies from a broadly spread arbor of supernumerary dendrites in the embryo to the single apical dendrite and lateral dendrites characteristic of the adult. At P0, MCs exhibit the immature dendritic morphology with a broadly spread arbor of a large number of relatively uniform dendrites. By P1, this arbor appears to have narrowed and one dendrite appears thicker than the others, probably on its way to differentiating into an apical dendrite. At P4, two clearly distinguishable subpopulations of neurons have clearly emerged, but some cells exhibit two apical dendrites. By P8, MCs appear to have an adult dendritic morphology.
Quantitative analysis of CDA 1 expression patterns in the OB at postnatal day 0, 2, 4, 8, suggests intra- and interlaminar patterns of dendritic development. Preliminary data further suggest distinct temporal windows of MC dendritic development along the rostrocaudal axis. CDA 1 expression in all laminae decreases significantly by postnatal day 8 and appears indistinguishable from background in the adult. Thus, both lines of data show evidence of significant postnatal dendritic remodeling.
Advisor:Charles A. Greer
School Location:USA - Connecticut
Source Type:Master's Thesis
Keywords:dendrites mice growth development olfactory bulb neurology and neurobiology
Date of Publication:02/11/2008