Methoden zur Unterstützung der klinischen Entscheidungsfindung in der Nierentransplantation
This work aims to investigate the communicability of the necessary skills for the application of Evidence-based Medicine in everyday clinical decision making. In addition the publication quality and design of clinical trials in the field of kidney transplantation are observed. In this context and on the background of the lack of clinically relevant study data for many important aspects of transplantation medicine alternative methods of knowledge generation to support clinical decision making are assessed. Whenever results of adequate prospective randomized trials are available clinical decision making should take these into account. But clinical decision making can be supported in various ways. The best way is the conduction of randomized clinical trials based on the results of basic science investigations. Use of randomized trial results requires their guideline-conforming publication and on the reader’s side the corresponding methodological skills for the critical interpretation and assessment of the scientific medical literature. Complementary methods - especially analyses of clinical databases can achieve substantial enhancement of the foundation for clinical decision making. They can also help to prepare the conduct of further randomized studies. Thus, as in other fields it seems worthwile to expand the existing databases in the field of kidney transplantation.
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School:Humboldt-Universität zu Berlin
Source Type:Master's Thesis
Date of Publication:07/07/2004