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Melanopsin polymorphisms in seasonal affective disorder /

by Roecklein, Kathryn Ariel

Abstract (Summary)
Title of Thesis: Melanopsin Polymorphisms in Seasonal Affective Disorder Kathryn Ariel Roecklein, Master of Science, 2005 Thesis directed by: Kelly J. Rohan, Ph.D. Assistant Professor Department of Medical and Clinical Psychology Seasonal affective disorder (SAD) is characterized by winter depressive episodes and springtime remission. SAD may result from a genetically-mediated abnormal response to low light availability during winter. One candidate gene for SAD is melanopsin, a non-visual, circadian photopigment. The present study determined the frequency of a genetic polymorphism in melanopsin (P10L) in individuals with SAD (n = 36) compared to two groups: gender-matched controls with no history of depression and minimal seasonality (n = 22) and a larger comparison group of samples obtained from NIH that have been delinked from identifying information (n = 84). The proportion of SAD participants with P10L (28%) did not differ significantly from the comparison group (15%) or nondepressed controls (18%). A post-hoc power analysis revealed that a sample of 200 participants would be required in future studies. If a sufficiently sized sample including gender- and ethnicity-matched controls becomes available, then the study should be repeated. iii Seasonal Affective Disorder and Melanopsin
Bibliographical Information:

Advisor:

School:Uniformed Services University of the Health Sciences

School Location:USA - Maryland

Source Type:Master's Thesis

Keywords:seasonal affective disorder retinal pigments melanopsin opsin melatonin circadian rhythm polymorphism genetic amino acid sequence depressive depression mood light photoperiod phototransduction photoreceptors molecular data seasons ganglion cells suprachiasmatic nucleus comparative study time factors

ISBN:

Date of Publication:01/01/2005

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