Mechanisms for Growth and Persistence of Francisella tularensisWithin Macrophages: a Role for iglC
Abstract (Summary)Francisella tularensisis a gram negative bacteria that is an intracellular pathogen that infects host macrophages. F. ularensissubspecies are able to survive and persist within macrophages and the bacterium employs various novel virulence mechanisms in order to persist. The gene iglC, intracellular growth locus C, was first identified to be involved in controlling intracellular growth. iglChas been shown to be important for manipulating the phagocytosis pathway, inducing host cell apoptosis and suppressing macrophage responses vital to clearing the infection. The work presented here focuses on delineating the mechanisms by which iglCallows F. novicidathe ability to grow and persist within macrophages. Intracellular growth, control of pro-inflammatory responses, effects of IFNã activation and the role of TLR4 responses were studied in order to better understand the virulence mechanisms of F. novicidaand the role iglCplays in this modulation of host and bacterial cell function.
School Location:USA - Ohio
Source Type:Master's Thesis
Keywords:francisella iglc macrophage
Date of Publication:01/01/2007