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KINETICS AND PASSIVE PROTECTION EFFICACY INDUCED BY PURIFIED AVA HUMAN IMMUNOGLOBULIN G IN RABBITS AGAINST A Bacillus anthracis AEROSOL CHALLENGE

by Plahovinsak, Jennifer Lee

Abstract (Summary)
The present study was conducted to determine the half-life, assess the toxicity, and passive protection efficacy of purified immunoglobulin G (IgG) from Anthrax Vaccine Adsorbed (AVA) vaccinated human donors. Half-life determinations were calculated from the reportable values obtained using the anti-PA ELISA assay and the Centers for Disease Control’s (CDC) “ELISA for Windows” software. For toxicity evaluations animals were observed clinical for one hour post administration and for 14-days post-treatment. The protection efficacy was determined based upon the mortality results from a lethal Bacillus anthracis aerosol challenge. While no protection was achieved in this delayed exposure scenario, the study yielded valuable kinetics data for use in future research.
Bibliographical Information:

Advisor:

School:Wright State University

School Location:USA - Ohio

Source Type:Master's Thesis

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ISBN:

Date of Publication:01/01/2006

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