KINETICS AND PASSIVE PROTECTION EFFICACY INDUCED BY PURIFIED AVA HUMAN IMMUNOGLOBULIN G IN RABBITS AGAINST A Bacillus anthracis AEROSOL CHALLENGE
Abstract (Summary)The present study was conducted to determine the half-life, assess the toxicity, and passive protection efficacy of purified immunoglobulin G (IgG) from Anthrax Vaccine Adsorbed (AVA) vaccinated human donors. Half-life determinations were calculated from the reportable values obtained using the anti-PA ELISA assay and the Centers for Disease Control’s (CDC) “ELISA for Windows” software. For toxicity evaluations animals were observed clinical for one hour post administration and for 14-days post-treatment. The protection efficacy was determined based upon the mortality results from a lethal Bacillus anthracis aerosol challenge. While no protection was achieved in this delayed exposure scenario, the study yielded valuable kinetics data for use in future research.
School:Wright State University
School Location:USA - Ohio
Source Type:Master's Thesis
Date of Publication:01/01/2006