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Kinetic isotope effect in the [beta]-subunit mechanism of tryptophan synthase ; excited state tautomerization of azaindole

by (Michael Todd), 1975- Cash

Abstract (Summary)
In Chapter I of this thesis, the ?-subunit mechanism of tryptophan synthase is investigated. We explored the addition of indole to the preformed aminoacrylate L- serine-enzyme complex to form an indolenine quinonoid intermediate. A kinetic isotope effect (KIE) is observed in the tautomerization of the indolenine quinonoid intermediate, and the KIE is dependent on the presence of allosteric ligands.
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School:The University of Georgia

School Location:USA - Georgia

Source Type:Master's Thesis

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