Inflammatory Response and Oxidative Stress in Rats Selected for Intrinsic Aerobic Endurance Capacity
Innate inflammatory response is complex and involves biochemical processes leading to the activation of immune cells and subsequent production of a plethora of inflammatory mediators such as reactive oxygen species (ROS). To test the links between aerobic capacity, inflammation, ROS, and inflammatory diseases rat lines of Low Capacity Runners (LCR) and High Capacity Runners (HCR) were used. Substantial data suggests that these lines have separated for disease-related phenotypes such as blood pressure and insulin resistance. Because of the widespread association of inflammation with many diseases, we tested the hypothesis that LCR and HCR differ in their acute inflammatory response. The LCR and HCR were challenged with carrageenan, a pro-inflammatory polysaccharide. LCR accumulated 3.2_fold more exudate compared to HCR (p?0.0001). These results could not be explained at the level of macrophages oxidative burst. The differential innate immune response between HCR and LCR is a disease-related phenotype, which requires further work to be more understood.
School:University of Toledo Health Science Campus
School Location:USA - Ohio
Source Type:Master's Thesis
Keywords:aerobic capacity oxidative stress innate immune response animal model of health and disease
Date of Publication:01/01/2007