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In vitro partial-body dose assessment using a radiation responsive protein biomarker /

by Leidel, Jason M.

Abstract (Summary)
Title of Thesis: “In Vitro Partial-Body Dose Assessment Using a Radiation Responsive Protein Biomarker” Author: Lt Jason M. Leidel Master of Science in Public Health Thesis Directed by: Dr. William F. Blakely Adjunct Professor of Preventive Medicine and Biometrics, Uniformed University of the Health Sciences. Exposure of humans, accidental or occupational, to ionizing radiation poses significant health hazards. The objective of this study was to evaluate the response of a radiation responsive protein biomarker after a simulated partial-body ionizing radiation exposure. The radiation responsive protein biomarker studied was Growth Arrest DNA-Damage (GADD-45)?. For a 6-Gray gamma dose, the GADD-45? signal increased linearly as the percentage irradiated increased. These results support the use of molecular biomarkers to contribute in a multi-parameter diagnostic strategy for radiation exposure assessment.
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School:Uniformed Services University of the Health Sciences

School Location:USA - Maryland

Source Type:Master's Thesis

Keywords:flow cytometry up regulation sensitivity and specificity occupational exposure health disaster planning risk assessment terrorism national security biological markers blood proteins assay immunoassay radiation ionizing dosage dose response relationship monitoring cobalt radioisotopes gamma rays microspheres nuclear dna damage repair gene expression

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