Document Text (Pages 141-150) Back to Document

In Silico Drug Design of Biofilm Inhibitors of Staphylococcus epidermidis

by Al-mulla, Aymen Faraoun, MS


Page 141

ميق نم رهظت اهتمئلامو فدهلا نيتوربلاب ةيوايميكلا تائيزجلا طابترا طمن ددحي يذلا
ينورتكللاا عقوملا يف دمتعم يثحبلا كرحملا اذهو ، طابترلال ةمزلالا ةبلاسلا ةقاطلا
.تائيزجلا نيب طابترلااو ءاسرلاا تاساردب صتخملا )Swissdock(
ثيح ةيويحلا ةيشغلأا يف اهريثأت ةفرعمو ايربتخم اهتبرجتل تائيزج 8

رايتخا مت مث
جئاتنلا تناكو ةيويحلا ةيشغلأا ةيلاعف طيبثت يف ايباجيإ اريثأت اهنم تائيزج 4

ترهظأ
:يتلآاك
ةيويحلا ةيشغلأل %811

.لم/مغلم 8.9 زيكرتب
براقت طيبثت ةبسن ترهظأ لوماتيساربلا ةئيزج

%811
.لم/مغلم 1.9 زيكرتب
.لم/مغلم 8 زيكرتب %27
.لم/مغلم88 زيكرتب
براقت طيبثت ةبسن ترهظأ نيربسلأا ةئيزج
%27

طيبثت ةبسن ترهظأ نيفوربلا ةئيزج
طيبثت ةبسن ترهظأ كيلخلا ضماح ةئيزج
.ايرتكبلا ومن يف رثؤت ملو ةيويحلا ةيشغلاا يف اهريثأت ناك ةروكذملا زيكارتلا لك
،%91 ىلا لصت ةبسنب يئاودلا ميمصتلا قرط ةيلعاف جاتنتسا مت ةساردلا نمو
،نيفوربلا ،نيربسلأا ،لوماتيساربلا( ةبجوملا جئاتنلا تاذ داوملا مادختسا نكمي امك
ةيئاودلا ةلئاعلا مادختسا

.8

.2
.2
.4

نكميو .ةيويحلا ةيشغلأل تاداضمك )كيلخلا ضماح
يف ةيويحلا ةيشغلأل طيبثت ةيلاعف تاذ تائيزج نع ثحبلل عجرمك )NSAIDs(
ةيويحلا ةيشغلاا طيبثت ثوحب يف )sarA( نيتورب مادختسا نكمي امك.لبقتسملا
.ضرغلا اذهل ديج فدهك


Page 142

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